In vitro activity of LY333328, an investigational glycopeptide antibiotic, against enterococci and staphylococci

被引：64

作者：

Schwalbe, RS

McIntosh, AC

Qaiyumi, S

Johnson, JA

Johnson, RJ

Furness, KM

Holloway, WJ

SteeleMoore, L

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201

[2] UNIV MARYLAND,SCH MED,DEPT MED & RES TECHNOL,BALTIMORE,MD 21201

[3] VET AFFAIRS MARYLAND HLTH CARE SYST,PATHOL & LAB MED SERV,BALTIMORE,MD 21201

[4] MED CTR DELAWARE,INFECT DIS LAB,WILMINGTON,DE 19899

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 10期

关键词：

D O I：

10.1128/AAC.40.10.2416

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of LY333328 were compared with those of vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MICs and MBCs were determined by a microtiter dilution protocol. LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal, Its potency was comparable or superior to those of other antibiotics tested against methicillin-resistant staphylococci.

引用

页码：2416 / 2419

页数：4

共 18 条

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