On the armament and appearances of human myeloid-derived suppressor cells

被引：168

作者：

Poschke, Isabel ^{[1
]}

Kiessling, Rolf ^{[1
]}

机构：

[1] Karolinska Inst, Dept Pathol & Oncol, Canc Ctr Karolinska R8 01, Stockholm, Sweden

来源：

CLINICAL IMMUNOLOGY | 2012年 / 144卷 / 03期

关键词：

MDSC; Cancer; Autoimmunity; Transplantation; CD4(+) T-CELLS; DENDRITIC CELL; IMMUNE SUPPRESSION; CANCER-PATIENTS; ARGINASE-I; IMMUNOSUPPRESSIVE ACTIVITY; HEPATOCELLULAR-CARCINOMA; HEMATOPOIETIC STEM; ANTITUMOR IMMUNITY; HYDROGEN-PEROXIDE;

D O I：

10.1016/j.clim.2012.06.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSC) have frequently been observed in patients with cancer. This heterogeneous population of myeloid cells can exert potent suppression of lymphocyte function and thereby poses a significant hurdle to natural or therapeutically induced anti-tumor immunity. On the other hand, the natural function of MDSC is not yet well understood and their role in infection, inflammation and autoimmune disease is still puzzling. Understanding MDSC biology will provide the tools necessary for therapeutic targeting of this population, but also permit exploitation of their strong tolerogenic function in the treatment of inflammatory conditions and the prevention of graft rejection. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：250 / 268

页数：19

共 150 条

[1] Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer [J].

Almand, B ;

Clark, JI ;

Nikitina, E ;

van Beynen, J ;

English, NR ;

Knight, SC ;

Carbone, DP ;

Gabrilovich, DI .

JOURNAL OF IMMUNOLOGY, 2001, 166 (01) :678-689

[2]

ALRAMADI BK, 1991, J IMMUNOL, V146, P2737

[3] Tcr ζ-chain downregulation:: Curtailing an excessive inflammatory immune response [J].

Baniyash, M .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (09) :675-687

[4] Extrinsic regulators of epithelial tumor progression: metalloproteinases [J].

Bergers, G ;

Coussens, LM .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) :120-127

[5] Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].

Bergers, G ;

Brekken, R ;

McMahon, G ;

Vu, TH ;

Itoh, T ;

Tamaki, K ;

Tanzawa, K ;

Thorpe, P ;

Itohara, S ;

Werb, Z ;

Hanahan, D .

NATURE CELL BIOLOGY, 2000, 2 (10) :737-744

[6] Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties [J].

Brandau, Sven ;

Trellakis, Sokratis ;

Bruderek, Kirsten ;

Schmaltz, Dominik ;

Steller, Gabriele ;

Elian, Motaz ;

Suttmann, Henrik ;

Schenck, Marcus ;

Welling, Juergen ;

Zabel, Peter ;

Lang, Stephan .

JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 89 (02) :311-317

[7] Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma [J].

Brimnes, M. K. ;

Vangsted, A. J. ;

Knudsen, L. M. ;

Gimsing, P. ;

Gang, A. O. ;

Johnsen, H. E. ;

Svane, I. M. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 72 (06) :540-547

[8] IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice [J].

Bronte, V ;

Serafini, P ;

De Santo, C ;

Marigo, I ;

Tosello, V ;

Mazzoni, A ;

Segal, DM ;

Staib, C ;

Lowel, M ;

Sutter, G ;

Colombo, MP ;

Zanovello, P .

JOURNAL OF IMMUNOLOGY, 2003, 170 (01) :270-278

[9] Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers [J].

Bronte, V ;

Kasic, T ;

Gri, G ;

Gallana, K ;

Borsellino, G ;

Marigo, I ;

Battistini, L ;

Iafrate, M ;

Prayer-Galetti, T ;

Pagano, F ;

Viola, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (08) :1257-1268

[10] Nature of Myeloid Cells Expressing Arginase 1 in Peripheral Blood After Trauma [J].

Bryk, Jodie A. ;

Popovic, Petar J. ;

Zenati, Mazen S. ;

Munera, Veronica ;

Pribis, John P. ;

Ochoa, Juan B. .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2010, 68 (04) :843-852

← 1 2 3 4 5 6 7 8 9 10 →