Sulfonylimidates as nucleophiles in catalytic addition reactions

被引：57

作者：

Matsubara, Ryosuke ^{[1
,2
,3
]}

Berthiol, Florian ^{[1
,2
,3
]}

Kobayashi, Shu ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy, HFRE Div, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 06期

关键词：

D O I：

10.1021/ja077054u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic addition reactions of sulfonylimidates have been accomplished. In the presence of a catalytic amount of DBU (normally 5-10 mol%), sulfonylimidates reacted with several N-protected imines, methyl acrylate, and azodicarboxylate to afford the corresponding addition adducts, sulfonylimidates, in excellent yields. In the addition reactions to imines, high anti-selectivity was observed. A novel direct formation of beta-amino acid derivatives from aldehyde and sulfonylimidate is also described.

引用

页码：1804 / +

页数：3

共 26 条

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