Regioselective lipase-catalysed acylation of 4,6-O-benzylidene-α- and -β-D-pyranoside derivatives displaying a range of anomeric substituents

被引：31

作者：

Gridley, JJ

Hacking, AJ

Osborn, HMI ^{[1
]}

Spackman, DG

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

[2] Univ Reading, Innovat Ctr, Dextra Labs, Reading RG6 6BX, Berks, England

来源：

TETRAHEDRON | 1998年 / 54卷 / 49期

关键词：

D O I：

10.1016/S0040-4020(98)00935-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The application of Lipase enzymes to effect regioselective C-3-O-acylation of 4,6-O-benzylidene-beta-D-gluco- and -galactopyranosides displaying a range of anomeric substituents, and C-2-O- acylation of phenyl 4,6-O-benzylidene-alpha-D-glucopyranoside and ethyl 4,6-O-benzylidene-1-thio-alpha-D-glucopyranoside is reported. In particular this method has allowed introduction of a variety of acyl protecting groups at the C-3 hydroxyl group of ethyl 4,6-O-benzylidene-1-thio-beta-D-glucopyranoside 11.(C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：14925 / 14946

页数：22

共 33 条

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