Quantitative evaluation of manganese-52m as a myocardial perfusion tracer in pigs using positron emission tomography

被引:22
作者
Buck, A
Nguyen, N
Burger, C
Ziegler, S
Frey, L
Weigand, G
Erhardt, W
SenekowitschSchmidtke, R
Pellikka, R
Blauenstein, P
Locher, JT
Schwaiger, M
机构
[1] TECH UNIV MUNICH, DEPT NUCL MED, D-8000 MUNICH, GERMANY
[2] KANTONSSPITAL, INST NUCL MED, AARAU, SWITZERLAND
来源
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1996年 / 23卷 / 12期
关键词
manganese; positron emission tomography; tracer kinetic modeling; myocardial perfusion;
D O I
10.1007/BF01249625
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
There is a need for a quantitative myocardial perfusion agent that does not require an on-site cyclotron, Early studies with manganese demonstrated that this trace metal is of potential use for myocardial imaging. Mn-52m can be produced in a Fe-52-Mn-52m generator and is suitable for positron emission tomographic (PET) imaging. The purpose of this study was to evaluate Mn-52m with regard to its potential to quantitatively assess myocardial perfusion, Dynamic PET imaging was performed in six pigs with various doses of dipyridamole to increase blood flow. Retention (R) and model-based K-1 values were correlated with microsphere blood flow. The models consisted of one (K-1, k(2)) and two (K-1, k(2), k(3)) tissue compartments. Anterior, lateral and septal regions showed a good myocardium-to-background ratio; the evaluation of the inferior wall was impaired by high liver uptake, Linear regression yielded the following equations: K-1=1.152 flow+0.059 (r=0.92), R=0.069 flow+0.034 (r=0.84), Based on these regressions, K-1 increased 2.7-fold and R 2.6-fold in the examined flow range of 0.5-2 ml/min/g (fourfold increase), demonstrating an underestimation of higher flow rates by both measures. It is concluded that Mn-52m allows the qualitative assessment of myocardial perfusion but does not meet the requirements of a quantitative myocardial perfusion agent.
引用
收藏
页码:1619 / 1627
页数:9
相关论文
共 31 条
[1]   MYOCARDIAL POSITRON TOMOGRAPHY WITH MANGANESE-52M [J].
ATKINS, HL ;
SOM, P ;
FAIRCHILD, RG ;
HUI, J ;
SCHACHNER, E ;
GOLDMAN, A ;
KU, T .
RADIOLOGY, 1979, 133 (03) :769-774
[2]  
BEANLANDS RSB, 1992, J NUCL MED, V33, P684
[3]  
BERGMANN SR, 1980, CIRCULATION, V61, P34, DOI 10.1161/01.CIR.61.1.34
[4]   QUANTIFICATION OF REGIONAL MYOCARDIAL BLOOD-FLOW INVIVO WITH (H2O)-O-15 [J].
BERGMANN, SR ;
FOX, KAA ;
RAND, AL ;
MCELVANY, KD ;
WELCH, MJ ;
MARKHAM, J ;
SOBEL, BE .
CIRCULATION, 1984, 70 (04) :724-733
[5]   EFFECT OF L-DOPA ON BRAIN CONCENTRATION OF DOPAMINE AND HOMOVANILLIC-ACID IN RATS AFTER CHRONIC MANGANESE CHLORIDE ADMINISTRATION [J].
BONILLA, E ;
DIEZEWAL.M .
JOURNAL OF NEUROCHEMISTRY, 1974, 22 (02) :297-299
[6]  
CHANCE B, 1965, J BIOL CHEM, V240, P2729
[7]  
CHAUNCEY DM, 1977, J NUCL MED, V18, P933
[8]  
Cotzias G C, 1974, Adv Neurol, V5, P235
[9]   STATE OF BINDING OF NATURAL MANGANESE IN HUMAN CEREBROSPINAL FLUID, BLOOD AND PLASMA [J].
COTZIAS, GC ;
PAPAVASILIOU, PS .
NATURE, 1962, 195 (4843) :823-&
[10]   ASSESSMENT OF CORONARY-ARTERY DISEASE SEVERITY BY POSITRON EMISSION TOMOGRAPHY - COMPARISON WITH QUANTITATIVE ARTERIOGRAPHY IN 193 PATIENTS [J].
DEMER, LL ;
GOULD, KL ;
GOLDSTEIN, RA ;
KIRKEEIDE, RL ;
MULLANI, NA ;
SMALLING, RW ;
NISHIKAWA, A ;
MERHIGE, ME .
CIRCULATION, 1989, 79 (04) :825-835