Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats

被引:153
作者
Fukushima, M [1 ]
Ohashi, T
Fujiwara, Y
Sonoyama, K
Nakano, M
机构
[1] Obihiro Univ Agr & Vet Med, Dept Bioresource Sci, Obihiro, Hokkaido 0808555, Japan
[2] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Lab Food Biochem, Sapporo, Hokkaido 0608589, Japan
关键词
rats; mushroom fiber; cholesterol; LDL receptor mRNA;
D O I
10.1177/153537020222600808
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effects of mushroom fibers on serum cholesterol and hepatic low-density lipoprotein (LDL) receptor mRNA in rats were investigated. Rats were fed a cholesterol-free diet with 50 g/kg cellulose powder (CP), 50 g/kg maitake (Grifola frondosa) fiber (MAF), 50 g/kg shiitake (Lentinus edodes) fiber (SF), or 50 g/kg enokitake (Flammulina velutipes) fiber (EF) for 4 weeks. There were no significant differences in the body weight, food intake, liver weight, cecum weight, and cecum pH among the groups. Cecal acetic acid, butyric acid, and total short-chain fatty acid (SCFA) concentrations in the SF and EF groups were significantly higher than those in the other groups. The serum total cholesterol concentration in the CP group was significantly higher than that in the MAF and EF groups. The very LDL (VLDL) + intermediate-density lipoprotein (IDL) + LDL-cholesterol concentration in the CP group was significantly higher than that in the MAF, SF, and EF groups, whereas the high-density lipoprotein (HDL)-cholesterol concentration in the EF group was significantly lower than that in the other groups at the end of the 4-week feeding period. The hepatic LDL receptor mRNA level in the EF group was significantly higher than that in the CP group. The fecal cholesterol excretion in the MAF, SF, and EF groups was significantly higher than that in the CP group. The results of this study demonstrate that MAF and EF lowered the serum total cholesterol level by enhancement of fecal cholesterol excretion, and in particular, by enhancement of hepatic LDL receptor mRNA in EF group.
引用
收藏
页码:758 / 765
页数:8
相关论文
共 30 条
[1]  
Bobek P, 1996, NAHRUNG, V40, P222, DOI 10.1002/food.19960400413
[2]   Dietary psyllium increases fecal bile acid excretion, total steroid excretion and bile acid biosynthesis in rats [J].
Buhman, KK ;
Furumoto, EJ ;
Donkin, SS ;
Story, JA .
JOURNAL OF NUTRITION, 1998, 128 (07) :1199-1203
[3]  
CHEN WJL, 1984, P SOC EXP BIOL MED, V175, P215, DOI 10.3181/00379727-175-41791
[4]   Plasma and hepatic cholesterol levels and fecal neutral sterol excretion are altered in hamsters fed straw mushroom diets [J].
Cheung, PCK .
JOURNAL OF NUTRITION, 1998, 128 (09) :1512-1516
[5]   SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].
CHOMCZYNSKI, P ;
SACCHI, N .
ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159
[6]  
FOLCH J, 1957, J BIOL CHEM, V226, P497
[7]   Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar beet fiber [J].
Fukushima, M ;
Nakano, M ;
Morii, Y ;
Ohashi, T ;
Fujiwara, Y ;
Sonoyama, K .
JOURNAL OF NUTRITION, 2000, 130 (09) :2151-2156
[8]   EFFECTS OF THE LIPID-SACCHARIDE COMPLEX AND UNSAPONIFIABLE MATTER FROM SUNFLOWERS ON LIVER LIPID-METABOLISM AND INTESTINAL FLORA IN RATS [J].
FURUSHIMA, M ;
NAKANO, M .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1995, 59 (05) :860-863
[9]   REGULATION OF THE MEVALONATE PATHWAY [J].
GOLDSTEIN, JL ;
BROWN, MS .
NATURE, 1990, 343 (6257) :425-430
[10]  
GRUNDY SM, 1965, J LIPID RES, V6, P397