Enantioselective Michael addition of β-keto esters to methyl vinyl ketone employing a chiral N,N′-dioxide-scandium trifluoromethanesulfonate complex as a catalyst

被引：57

作者：

Nakajima, M ^{[1
]}

Yamaguchi, Y ^{[1
]}

Hashimoto, S ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 17期

关键词：

D O I：

10.1039/b104876g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective Michael addition of beta -keto esters to methyl vinyl ketone exploiting a chiral N,N ' -dioxide-scandium. trifluoromethanesulfonate complex as a catalyst affords the corresponding Michael adducts in high yields and with enantioselectivities of up to 80% ee.

引用

页码：1596 / 1597

页数：2

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