Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections

被引：425

作者：

Weidenmaier, C

Kokai-Kun, JF

Kristian, SA

Chanturiya, T

Kalbacher, H

Gross, M

Nicholson, G

Neumeister, B

Mond, JJ

Peschel, A

机构：

[1] Univ Tubingen, Med Microbiol & Hyg Dept, D-72076 Tubingen, Germany

[2] Biosynexus Inc, Gaithersburg, MD 20877 USA

[3] Univ Tubingen, Dept Transfus Med, D-72076 Tubingen, Germany

[4] Univ Tubingen, Med & Nat Sci Res Ctr, D-72074 Tubingen, Germany

[5] Univ Tubingen, Dept Organ Chem, D-72076 Tubingen, Germany

来源：

NATURE MEDICINE | 2004年 / 10卷 / 03期

关键词：

D O I：

10.1038/nm991

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colonization of the anterior nares in 37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization.

引用

页码：243 / 245

页数：3

共 15 条

[1] ROLE OF TEICHOIC-ACID IN THE BINDING OF STAPHYLOCOCCUS-AUREUS TO NASAL EPITHELIAL-CELLS [J].