The purpose of this paper is to meta-analytically examine trait goal orientation constructs and their relationships with the self-regulation variables of self-monitoring, self-evaluations, self-reactions, and self-efficacy as well as task performance across a range of contexts. Data were gathered from published and unpublished research examining the goal orientation construct and self-regulation and/or task performance. Effect sizes from 102 research reports involving over 16,000 participants were included. In general the mastery-approach goal orientation construct was positively related to the self-regulation and performance variables. Conversely, negative relationships were found between the performance-avoid goal orientation and those variables. Relationships between goal orientation and self-regulation tended to be higher compared to those found for goal orientation and performance. Overall, the findings support the discriminant validity of the three factors of goal orientation (mastery-approach, performance-approach, performance-avoid). Practitioners and researchers will benefit from learning that mastery-approach goal orientation consistently relates to self-regulation and task performance. The findings indicate that a mastery-approach goal orientation could serve as a meaningful predictor in selection processes or as an explanatory variable of motivation. The present study updates and expands upon past research by focusing on relationships of trait goal orientation across a variety of contexts. The results extend meta-analytic results to a wider range of self-regulatory variables.