Immunomodulatory activity of Punica granatum in rabbits -: a preliminary study

被引:116
作者
Ross, RG [1 ]
Selvasubramanian, S [1 ]
Jayasundar, S [1 ]
机构
[1] Madras Vet Coll, Dept Pharmacol & Toxicol, Madras 600007, Tamil Nadu, India
关键词
Punica granatum; punicaccae; immunostimulatory; cell-mediated immunity; humoral immunity; rabbits;
D O I
10.1016/S0378-8741(01)00287-2
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Punica granatum L. (Punicaceae) fruit rind powder (PGFRP) at the dose of 100 mg/kg orally as aqueous suspension was found to stimulate the cell-mediated and humoral components of the immune system in rabbits. PGFRP elicited an increase in antibody titer to typhoid-H antigen. It also enhanced the inhibition of leucocyte migration in Leucocyte Migration Inhibition test and induration of skin in delayed hypersensitivity test with Purified Protein Derivative (PPD) confirming its stimulatory effect on cell-mediated immune response. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:85 / 87
页数:3
相关论文
共 9 条
[1]  
BENACERRAF B, 1978, J IMMUNOL, V120, P1809
[2]  
BENDIXEN G, 1969, DAN MED BULL, V16, P1
[3]   INVITRO ANTIBACTERIAL ACTIVITY OF OILS FROM INDIAN MEDICINAL PLANTS .1. [J].
CHOPRA, CL ;
BHATIA, MC ;
CHOPRA, IC .
JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1960, 49 (12) :780-781
[4]  
CRUIKSHANK R, MED MICROBIOLOGY, P906
[5]  
KENNETH CN, 1982, PHARMACOL REV, V34, P131
[6]   CELL-MEDIATED-IMMUNITY AND ITS APPLICATION IN TOXICOLOGY [J].
LUSTER, MI ;
DEAN, JH ;
BOORMAN, GA .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1982, 43 (FEB) :31-36
[7]  
Siegal S., 1988, NONPARAMETRIC STAT B
[8]  
Snedecor G.W. C., 1989, Statistical methods/George W. Snedecor and William G. Cochran
[9]  
Trivedi VB, 1979, INDIAN DRUGS, V16, P295