The Development and Application of Optogenetics

被引：1320

作者：

Fenno, Lief ^{[1
,2
]}

Yizhar, Ofer ^{[1
]}

Deisseroth, Karl ^{[1
,3
,4
,5
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Behav Sci, Stanford, CA 94305 USA

[5] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 | 2011年 / 34卷

关键词：

channelrhodopsin; halorhodopsin; bacteriorhodopsin; electrophysiology; RESTORES VISUAL RESPONSES; LIGHT-INDUCED ACTIVATION; IN-VIVO CONTROL; OPTICAL CONTROL; NEURAL ACTIVITY; REMOTE-CONTROL; 2-PHOTON EXCITATION; MILLISECOND-TIMESCALE; STRUCTURAL-CHANGES; DROSOPHILA LARVAE;

D O I：

10.1146/annurev-neuro-061010-113817

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues. As the optogenetic toolbox contents grow and diversify, the opportunities for neuroscience continue to grow. In this review, we outline the development of currently available single-component optogenetic tools and summarize the application of various optogenetic tools in diverse model organisms.

引用

页码：389 / 412

页数：24

共 163 条

[1] Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats [J].

Abbott, Stephen B. G. ;

Stornetta, Ruth L. ;

Socolovsky, Carmela S. ;

West, Gavin H. ;

Guyenet, Patrice G. .

JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (23) :5613-5631

[2] Photostimulation of Retrotrapezoid Nucleus Phox2b-Expressing Neurons In Vivo Produces Long-Lasting Activation of Breathing in Rats [J].

Abbott, Stephen B. G. ;

Stornetta, Ruth L. ;

Fortuna, Michal G. ;

Depuy, Seth D. ;

West, Gavin H. ;

Harris, Thurl E. ;

Guyenet, Patrice G. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (18) :5806-5819

[3] Neural substrates of awakening probed with optogenetic control of hypocretin neurons [J].

Adamantidis, Antoine R. ;

Zhang, Feng ;

Aravanis, Alexander M. ;

Deisseroth, Karl ;

De Lecea, Luis .

NATURE, 2007, 450 (7168) :420-U9

[4] Lateral competition for cortical space by layer-specific horizontal circuits [J].

Adesnik, Hillel ;

Scanziani, Massimo .

NATURE, 2010, 464 (7292) :1155-U71

[5] Temporally precise in vivo control of intracellular signalling [J].

Airan, Raag D. ;

Thompson, Kimberly R. ;

Fenno, Lief E. ;

Bernstein, Hannah ;

Deisseroth, Karl .

NATURE, 2009, 458 (7241) :1025-1029

[6] Light-Induced Rescue of Breathing after Spinal Cord Injury [J].

Alilain, Warren J. ;

Li, Xiang ;

Horn, Kevin P. ;

Dhingra, Rishi ;

Dick, Thomas E. ;

Herlitze, Stefan ;

Silver, Jerry .

JOURNAL OF NEUROSCIENCE, 2008, 28 (46) :11862-11870

[7] An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse [J].

Almedom, Ruta B. ;

Liewald, Jana F. ;

Hernando, Guillermina ;

Schultheis, Christian ;

Rayes, Diego ;

Pan, Jie ;

Schedletzky, Thorsten ;

Hutter, Harald ;

Bouzat, Cecilia ;

Gottschalk, Alexander .

EMBO JOURNAL, 2009, 28 (17) :2636-2649

[8] Two-photon single-cell optogenetic control of neuronal activity by sculpted light [J].

Andrasfalvy, Bertalan K. ;

Zemelman, Boris V. ;

Tang, Jianyong ;

Vaziri, Alipasha .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (26) :11981-11986

[9] An optical neural interface:: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology [J].

Aravanis, Alexander M. ;

Wang, Li-Ping ;

Zhang, Feng ;

Meltzer, Leslie A. ;

Mogri, Murtaza Z. ;

Schneider, M. Bret ;

Deisseroth, Karl .

JOURNAL OF NEURAL ENGINEERING, 2007, 4 (03) :S143-S156

[10] In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2 [J].

Arenkiel, Benjamin R. ;

Peca, Joao ;

Davison, Ian G. ;

Feliciano, Catia ;

Deisseroth, Karl ;

Augustine, George J. ;

Ehlers, Michael D. ;

Feng, Guoping .

NEURON, 2007, 54 (02) :205-218

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