Standardization of the endogenous thrombin potential measurement: how to minimize the effect of residual platelets in stored plasma

被引：14

作者：

Chantarangkul, V ^{[1
]}

Clerici, M ^{[1
]}

Bressi, C ^{[1
]}

Tripodi, A ^{[1
]}

机构：

[1] Univ & IRCCS Maggiore Hosp, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, Dept Internal Med, I-20122 Milan, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 124卷 / 03期

关键词：

thrombosis; hyper-coagulability; hypo-coagulability; standardization;

D O I：

10.1046/j.1365-2141.2003.04771.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet contamination in stored plasma may affect coagulation assays, including the endogenous thrombin potential (ETP), which has been proposed for the investigation of hyper- and hypo-coagulability. The current recommendation of filtering plasma before freezing cannot be always met. This study provides evidence that filtering frozen plasma after thawing, prior to testing, may help to eliminate the unwanted effect of residual platelets on the ETP. This may have important implications in future studies, as the ETP could be determined with plasma that have been collected without precautions relating to platelet contamination, as is the case for plasmas collected in epidemiological studies.

引用

页码：355 / 357

页数：3