The molecular biology of human herpesvirus-6 latency and telomere integration

被引：44

作者：

Arbuckle, Jesse H. ^{[1
]}

Medveczky, Peter G. ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Mol Med, Tampa, FL 33612 USA

来源：

MICROBES AND INFECTION | 2011年 / 13卷 / 8-9期

基金：

美国国家卫生研究院;

关键词：

HHV-6; iHHV-6; Telomere integration; Chromosome integration; Viral latency; Chromosomally integrated HHV-6; MAREKS-DISEASE VIRUS; CENTRAL-NERVOUS-SYSTEM; ADENOASSOCIATED-VIRUS; HUMAN-HERPESVIRUS-6; HHV-6; DNA-REPLICATION; CODING CONTENT; GENE-PRODUCT; CELL-LINES; REP GENE; BINDING;

D O I：

10.1016/j.micinf.2011.03.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：731 / 741

页数：11

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