Antigen-based immunotherapy for autoimmune disease: from animal models to humans?

被引：24

作者：

Tian, J ^{[1
]}

Olcott, A ^{[1
]}

Hanssen, L ^{[1
]}

Zekzer, D ^{[1
]}

Kaufman, DL ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(99)01445-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Insights into tolerance and autoimmune processes have led to novel immunotherapeutics for inhibiting autoimmune disease in animal models. However, recent studies question the immune basis of some of these therapeutic strategies and raise concerns about their efficacy and safety. Here, we discuss the feasibility of extending the success of antigen-based immunotherapeutics for T-cell mediated autoimmune diseases from animal models to humans.

引用

页码：190 / 195

页数：6

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