Synthesis and antidiabetic activity of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)quinoxalines and quinoxalin-2-yl isothioureas

被引：36

作者：

Bahekar, Rajesh H. ^{[1
]}

Jain, Mukul R. ^{[1
]}

Gupta, Arun A. ^{[1
]}

Goel, Ashish ^{[1
]}

Jadav, Pradip A. ^{[1
]}

Patel, Dipam N. ^{[1
]}

Prajapati, Vijay M. ^{[1
]}

Patel, Pankaj R. ^{[1
]}

机构：

[1] Cadila Healthcare Ltd, Zydus Res Ctr, Ahmadabad 382210, Gujarat, India

来源：

ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 07期

关键词：

antidiabetic; imidazol-2-ylsulfanyl; insulinotropic; isothiourea; quinoxaline;

D O I：

10.1002/ardp.200700024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)-quinoxalines 2a-1 and 2-(quinoxalin2-yl)-isothioureas 3a-1 were prepared. All the test compounds 2a-1 and 3a-1 were screened in vitro, in a RIN517 cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-1 and the insulinotropic activity of compound 21 was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4-thiadiazo-2-ylsulfanyl)-quinoxaline (1)).

引用

页码：359 / 366

页数：8

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