Protein design: a perspective from simple tractable models

被引：140

作者：

Shakhnovich, EI ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

FOLDING & DESIGN | 1998年 / 3卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1359-0278(98)00021-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress in computational approaches to protein design builds on advances in statistical mechanical protein folding theory. Here, the number of sequences folding into a given conformation is evaluated and a simple condition for a protein model's designability is outlined. (C) Current Biology Ltd ISSN 1359-0278.

引用

页码：R45 / R58

页数：14

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