Neonatal dendritic cells

被引：52

作者：

Petty, RE ^{[1
]}

Hunt, DWC

机构：

[1] Univ British Columbia, Dept Pediat, Div Rheumatol, Vancouver, BC V6T 1W5, Canada

[2] QLT Phototherapeut Inc, Vancouver, BC, Canada

来源：

VACCINE | 1998年 / 16卷 / 14-15期

关键词：

dendritic cells; cord blood; neonatal immunity;

D O I：

10.1016/S0264-410X(98)00095-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The capacity of lymphoid dendritic cells from human cord blood or adult peripheral blood to support a mixed leukocyte reaction in cord blood and adult T cells has been compared. Cord blood dendritic cells have a limited ability to induce either adult or cord blood T cells to proliferate in response to typical concentration of phytohemagglutinin or concanavalin A. Adult blood dendritic cells, on the other hand, induce equivalent mitogen responses in cord blood and adult blood T cells. This relative deficiency can be overcome by increasing the concentration of mitogen or the numbers of dendritic cells in the culture. Neonatal primary immune responses may, in part, reflect the reduced function of dendritic cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1378 / 1382

页数：5

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