Nanofibers Self-assembled from Structural Complementary Borono-decapeptides

被引：22

作者：

Chen, Chang-Sheng ^{[1
,2
]}

Ji, Tian-Jiao ^{[1
,2
]}

Xu, Xiao-Ding ^{[1
,2
]}

Zhang, Xian-Zheng ^{[1
,2
]}

Zhuo, Ren-Xi ^{[1
,2
]}

机构：

[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2010年 / 31卷 / 21期

基金：

中国国家自然科学基金;

关键词：

nanofibers; peptide; structural complementary; self-assembly; FOLDING DNA; PROTEIN; HELIX; AMPHIPHILES; MORPHOLOGY; HYDROGEL; BINDING; PH;

D O I：

10.1002/marc.201000292

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

A series of structural complementary decapeptides with phenyl boronic acid tails or borono-decapeptides (BPs) were designed and synthesized for supramolecular self-assembly. After dissolving these borono-decapeptides in deionized (DI) water, well-defined nanofibers were formed in BP1 (B(OH)(2)VEKELVKEKL-OH) and BP3 (B(OH)(2)AELELARARL-OH). It was found that the self-assembled borono-decapeptide BP1 and BP3 have a parallel beta-sheet conformation in the formed nanofibers. The strategy demonstrated here shows a great prospect in preparation of well-ordered nanofibers via rationally designing the molecular structures of peptides.

引用

页码：1903 / 1908

页数：6

共 40 条

[1]

pH as a trigger of peptide β-sheet self-assembly and reversible switching between nematic and isotropic phases [J].