Ground-Glass Nodules on Chest CT as Imaging Biomarkers in the Management of Lung Adenocarcinoma

被引:112
作者
Goo, Jin Mo [1 ,2 ]
Park, Chang Min [1 ,2 ]
Lee, Hyun Ju [1 ,2 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul 110744, South Korea
[2] Seoul Natl Univ, Inst Radiat Med, Med Res Ctr, Seoul 110744, South Korea
关键词
bronchioloalveolar carcinoma; CT; ground-glass opacity; lung cancer; nodule; THIN-SECTION CT; GROWTH-FACTOR-RECEPTOR; HIGH-RESOLUTION CT; SMALL PERIPHERAL ADENOCARCINOMA; COMPUTED-TOMOGRAPHY; BRONCHIOLOALVEOLAR CARCINOMA; OPACITY NODULES; FOLLOW-UP; CLINICAL-SIGNIFICANCE; LIMITED RESECTION;
D O I
10.2214/AJR.10.5813
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
OBJECTIVE. The purpose of this article is to review the clinical significance of ground-glass nodules (GGNs) in the management of lung adenocarcinoma. CONCLUSION. GGNs can serve as imaging biomarkers that represent the bronchioloalveolar carcinoma component in adenocarcinoma on histology and indicate a better prognosis in patients with lung adenocarcinoma. The evolution of GGNs reflects the multistep progression of adenocarcinoma. Despite the high probability of malignancy of GGNs, the possibility of overdiagnosis should be considered in the management of GGNs.
引用
收藏
页码:533 / 543
页数:11
相关论文
共 77 条
[1]
[Anonymous], 1995, Ann. Thorac. Surg, DOI 10.1016/0003-4975
[2]
Peripheral lung adenocarcinoma: Correlation of thin-section CT findings with histologic prognostic factors and survival [J].
Aoki, T ;
Tomoda, Y ;
Watanabe, H ;
Nakata, H ;
Kasai, T ;
Hashimoto, H ;
Kodate, M ;
Osaki, T ;
Yasumoto, K .
RADIOLOGY, 2001, 220 (03) :803-809
[3]
Minimally invasive approach to early, peripheral adenocarcinoma with ground-glass opacity appearance [J].
Asamura, Hisao .
ANNALS OF THORACIC SURGERY, 2008, 85 (02) :S701-S704
[4]
Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation [J].
Blons, Helene ;
Cote, Jean-Francois ;
Le Corre, Delphine ;
Riquet, Marc ;
Fabre-Guilevin, Elisabeth ;
Laurent-Puig, Pierre ;
Danel, Claire .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (10) :1309-1315
[5]
Comparison of pathologic findings of baseline and annual repeat cancers diagnosed on CT screening [J].
Carter, Darryl ;
Vazquez, Madeline ;
Flieder, Douglas B. ;
Brambilla, Elizabeth ;
Gazdar, Adi ;
Noguchi, Masayuki ;
Travis, William D. ;
Kramer, Arin ;
Yip, Rowena ;
Yankelevitz, David F. ;
Henschke, Claudia I. .
LUNG CANCER, 2007, 56 (02) :193-199
[6]
The increasing incidence of lung adenocarcinoma: Reality or artefact? A review of the epidemiology of lung adenocarcinoma [J].
Charloux, A ;
Quoix, E ;
Wolkove, N ;
Small, D ;
Pauli, G ;
Kreisman, H .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1997, 26 (01) :14-23
[7]
Differentiation between malignancy and inflammation in pulmonary ground-glass nodules: The feasibility of integrated 18F-FDG PET/CT [J].
Chun, Eun Ju ;
Lee, Hyun Ju ;
Kang, Won Jun ;
Kim, Kwang Gi ;
Goo, Jin Mo ;
Park, Chang Min ;
Lee, Chang Hyun .
LUNG CANCER, 2009, 65 (02) :180-186
[8]
Epidermal Growth Factor Receptor Mutation and Pathologic-Radiologic Correlation Between Multiple Lung Nodules with Ground-Glass Opacity Differentiates Multicentric Origin from Intrapulmonary Spread [J].
Chung, Jin-Haeng ;
Choe, Gheeyoung ;
Jheon, Sanghoon ;
Sung, Sook-Whan ;
Kim, Tae Jung ;
Lee, Kyung Won ;
Lee, Jae Ho ;
Lee, Choon-Taek .
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (12) :1490-1495
[9]
A comparison of six software packages for evaluation of solid lung nodules using semi-automated volumetry: What is the minimum increase in size to detect growth in repeated CT examinations [J].
de Hoop, Bartjan ;
Gietema, Hester ;
van Ginneken, Bram ;
Zanen, Pieter ;
Groenewegen, Gerard ;
Prokop, Mathias .
EUROPEAN RADIOLOGY, 2009, 19 (04) :800-808
[10]
FELIX L, EUR J RADIOL