A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis

被引：11

作者：

Coraddu, F

Lai, M

Mancosu, C

Cocco, E

Sawcer, S

Setakis, E

Compston, A

Marrosu, MG

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[2] Univ Cagliari, Dipartimento Neurosci, Ctr Sclerosi Multipla, Osped Binaghi, I-09126 Cagliari, Italy

[3] Inst Publ Hlth, MRC Biostat Unit, Cambridge CB10 1SB, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

关键词：

multiple sclerosis; genetically isolated; genome screen; linkage disequilibrium;

D O I：

10.1016/j.jneuroim.2003.08.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using indirect whole genome association screening, we have searched for multiple sclerosis susceptibility genes in the genetically isolated high risk Sardinian population. Two screens were performed; the first was based on 229 cases and 264 unrelated controls, and the second on 235 trio families. Each screen employed a dense set of microsatellite markers and DNA pooling. Data from both screens were available from 2764 markers. Nine markers showed nominally significant results in both screens independently. Five of these markers-D2S408 (2q36), D6S271 (6p21), D6S344 (6p25), D7S1818 (7p12) and D16S420 (16p12)-remained nominally significant in both studies after conservative refining analysis. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：120 / 123

页数：4

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