Evaluation of the Antiviral Response to Zanamivir Administered Intravenously for Treatment of Critically Ill Patients With Pandemic Influenza A (H1N1) Infection

被引：33

作者：

Fraaij, P. L. A. ^{[1
,2
]}

van der Vries, E. ^{[1
]}

Beersma, M. F. C. ^{[1
]}

Riezebos-Brilman, A. ^{[3
]}

Niesters, H. G. M. ^{[3
]}

van der Eijk, A. A. ^{[1
]}

de Jong, M. D. ^{[4
]}

Miranda, D. Reis ^{[5
]}

Horrevorts, A. M. ^{[6
]}

Ridwan, B. U. ^{[7
]}

Wolfhagen, M. J. H. M. ^{[8
]}

Houmes, R. J. ^{[2
]}

van Dissel, J. T. ^{[9
]}

Fouchier, R. A. M. ^{[1
]}

Kroes, A. C. M. ^{[9
]}

Koopmans, M. P. ^{[10
]}

Osterhaus, A. D. M. E. ^{[1
]}

Boucher, C. A. B. ^{[1
]}

机构：

[1] Erasmus MC, Dept Virol, NL-2040 Rotterdam, Postbus, Netherlands

[2] Sophia Childrens Univ Hosp, Erasmus MC, Dept Pediat Surg & Pediat, Rotterdam, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, Div Clin Virol, Rotterdam, Netherlands

[4] Univ Amsterdam, Dept Med Microbiol & Infect Dis, Acad Med Ctr, Rotterdam, Netherlands

[5] Erasmus MC, Dept Intens Care, Rotterdam, Netherlands

[6] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[7] Westfriesgasthuis, Dept Med Microbiol, Hoorn, Netherlands

[8] Isala Clin, Lab Med Microbiol & Infect Dis, Zwolle, Netherlands

[9] Leiden Univ, Med Ctr, Ctr Infect Dis, NL-2300 RA Leiden, Netherlands

[10] Natl Inst Publ Hlth & Environm RIVM, Infect Dis Lab & Perinatal Screening, Bilthoven, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 05期

关键词：

A(H1N1);

D O I：

10.1093/infdis/jir397

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A retrospective nationwide study on the use of intravenous (IV) zanamivir in patients receiving intensive care who were pretreated with oseltamivir in the Netherlands was performed. In 6 of 13 patients with a sustained reduction of the viral load, the median time to start IV zanamivir was 9 days (range, 4-11 days) compared with 14 days (range, 6-21 days) in 7 patients without viral load reduction (P = .052). Viral load response did not influence mortality. We conclude that IV zanamivir as late add-on therapy has limited effectiveness. The effect of an immediate start with IV zanamivir monotherapy or in combination with other drugs need to be evaluated.

引用

页码：777 / 782

页数：6

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