Antiproliferative, anti-aromatase, anti-17β-HSD and antioxidant activities of lignans isolated from Myristica argentea

被引：42

作者：

Filleur, F ^{[1
]}

Le Bail, JC ^{[1
]}

Duroux, JL ^{[1
]}

Simon, A ^{[1
]}

Chulia, AJ ^{[1
]}

机构：

[1] UFR Pharm, UPRES EA 1085, Lab Pharmacognosie, F-87025 Limoges, France

来源：

PLANTA MEDICA | 2001年 / 67卷 / 08期

关键词：

Myristica argentea; Myristicaceae; lignans; antiproliferative activity; antioxidant activity; anti-17 beta-HSD activity; anti-aromatase activity;

D O I：

10.1055/s-2001-18349

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four lignans were isolated from the petrol extract of Myristica argentea mace (Myristicaceae) and their structures were elucidated by means of NMR and mass spectrometry. Although they have been previously described, NMR data are only available for threo-austrobailignan-5, which has been isolated only once, and is incomplete. Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1 -diphenyl-2-picrylhydrazyl(DPPH) radical, but not the threo-austrobailignan-5. Nectandrin-B also possesses anti-17 beta -hydroxysteroid dehydrogenase and anti-aromatase activities.

引用

页码：700 / 704

页数：5

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