Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats

被引:28
作者
Gallego, M
Espiña, L
Vegas, L
Echevarria, E
Iriarte, MM
Casis, O
机构
[1] Univ Basque Country, Sch Pharm, Dept Physiol, Bilbao 48080, Spain
[2] Fdn Res & Teaching Cardiovasc Dis, Bilbao, Spain
关键词
spironolactone; captopril; cardiac fibrosis;
D O I
10.1006/phrs.2001.0865
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The role of renin-angiotensin-aldosterone system in cardiac remodelling was studied in isoproterenol-induced cardiac hypertrophy in rats. The effects of captopril and spironolactone were compared. Isoproterenol treatment increased ventricular to body weight ratio (4.6 vs 3.7) and collagen area (22.6 vs 8.2%), and reduced systolic (89.93 vs 107.5 mm Hg) and diastolic (59.6 vs 70.8 mm Hg) pressure. In these animals, captopril decreased systolic (67.4 mm Hg) and diastolic pressure (31.9 mm Hg), whereas spironolactone regressed systolic pressure to control values (101.2 mm Hg). Captopril and spironolactone prevented cardiac hypertrophy (4.01 and 3.95). However, only spironolactone prevented myocardial fibrosis (11.3%). (C) 2001 Academic Press.
引用
收藏
页码:311 / 315
页数:5
相关论文
共 23 条
[1]   ANGIOTENSIN-CONVERTING ENZYME-INHIBITION PREVENTS THE INCREASE IN AORTIC COLLAGEN IN RATS [J].
ALBALADEJO, P ;
BOUAZIZ, H ;
DURIEZ, M ;
GOHLKE, P ;
LEVY, BI ;
SAFAR, ME ;
BENETOS, A .
HYPERTENSION, 1994, 23 (01) :74-82
[2]  
Allard M F, 1990, Am J Cardiovasc Pathol, V3, P167
[3]   Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats [J].
Benetos, A ;
Lacolley, P ;
Safar, ME .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (06) :1152-1156
[4]   IMPAIRED DIASTOLIC FUNCTION AND CORONARY RESERVE IN GENETIC-HYPERTENSION - ROLE OF INTERSTITIAL FIBROSIS AND MEDIAL THICKENING OF INTRAMYOCARDIAL CORONARY-ARTERIES [J].
BRILLA, CG ;
JANICKI, JS ;
WEBER, KT .
CIRCULATION RESEARCH, 1991, 69 (01) :107-115
[5]   COLLAGEN-METABOLISM IN CULTURED ADULT-RAT CARDIAC FIBROBLASTS - RESPONSE TO ANGIOTENSIN-II AND ALDOSTERONE [J].
BRILLA, CG ;
ZHOU, GP ;
MATSUBARA, L ;
WEBER, KT .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1994, 26 (07) :809-820
[6]  
GOLDSTEIN RH, 1982, J BIOL CHEM, V257, P8630
[7]   ANGIOTENSIN-II MAINTAINS, BUT DOES NOT MEDIATE, ISOPROTERENOL-INDUCED CARDIAC-HYPERTROPHY IN RATS [J].
GOLOMB, E ;
ABASSI, ZA ;
CUDA, G ;
STYLIANOU, M ;
PANCHAL, VR ;
TRACHEWSKY, D ;
KEISER, HR .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1994, 267 (04) :H1496-H1506
[8]   Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system [J].
Grimm, D ;
Elsner, D ;
Schunkert, H ;
Pfeifer, M ;
Griese, D ;
Bruckschlegel, G ;
Muders, F ;
Riegger, GAJ ;
Kromer, EP .
CARDIOVASCULAR RESEARCH, 1998, 37 (01) :91-100
[9]   Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol - Induced heart failure in the rat [J].
Grimm, D ;
Holmer, SR ;
Riegger, GAJ ;
Kromer, EP .
CARDIOVASCULAR PATHOLOGY, 1999, 8 (06) :315-323
[10]   FIBRILLAR COLLAGEN AND MYOCARDIAL STIFFNESS IN THE INTACT HYPERTROPHIED RAT LEFT-VENTRICLE [J].
JALIL, JE ;
DOERING, CW ;
JANICKI, JS ;
PICK, R ;
SHROFF, SG ;
WEBER, KT .
CIRCULATION RESEARCH, 1989, 64 (06) :1041-1050