Repair of dGMP hydroxyl radical adducts by verbascoside via electron transfer: A pulse radiolysis study

被引：34

作者：

Li, WY

Zheng, RL

Su, BN

Jia, ZJ

Li, HC

Jiang, Y

Yao, S

Lin, NY

机构：

[1] LANZHOU UNIV, DEPT BIOL, LANZHOU 730000, PEOPLES R CHINA

[2] LANZHOU UNIV, INST ORGAN CHEM, LANZHOU 730000, PEOPLES R CHINA

[3] ACAD SINICA, SHANGHAI INST NUCL RES, LAB RADIAT CHEM, SHANGHAI 201800, PEOPLES R CHINA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1996年 / 69卷 / 04期

关键词：

D O I：

10.1080/095530096145779

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it was found that the transient absorption spectrum of the hydroxyl adduct of dGMP decays with the formation of that of the phenoxyl radical of VER, several tens of microseconds after the electron pulse. From the formation kinetics of the phenoxyl radical of VER, the rate constant of the repair reaction was determined to be 1.12 x 10(9) dm(3) mol(-1) s(-1).

引用

页码：481 / 485

页数：5

共 28 条

[1] ENDOGENOUS MUTAGENS AND THE CAUSES OF AGING AND CANCER [J].