Design and self-assembly of two-dimensional DNA crystals

被引:2210
作者
Winfree, E [1 ]
Liu, FR
Wenzler, LA
Seeman, NC
机构
[1] CALTECH, Pasadena, CA 91125 USA
[2] NYU, Dept Chem, New York, NY 10003 USA
关键词
D O I
10.1038/28998
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.
引用
收藏
页码:539 / 544
页数:6
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