An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

被引：83

作者：

Bastani, Sepideh ^{[1
]}

Vahedian, Vahid ^{[2
]}

Rashidi, Mohsen ^{[3
,4
]}

Mir, Amirabbas ^{[5
]}

Mirzaei, Sepideh ^{[6
]}

Alipourfard, Iraj ^{[7
]}

Pouremamali, Farhad ^{[8
]}

Nejabati, Hamidreza ^{[9
]}

Kadkhoda, Jamileh ^{[10
]}

Maroufi, Nazila Fathi ^{[9
]}

Akbarzadeh, Maryam ^{[11
]}

机构：

[1] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran

[2] Sao Paulo State Univ UNESP, Fac Med Inst Biotechnol FMB IBTEC, Canc Biol Res Grp, Sao Paulo, Brazil

[3] Mazandaran Univ Med Sci, Fac Med, Dept Pharmacol, Sari, Iran

[4] Mazandaran Univ Med Sci, Hlth Plant & Livestock Prod Res Ctr, Sari, Iran

[5] Univ Kashan, Inst Nano Sci & Nano Technol, Box 87317-51167, Kashan, Iran

[6] Islamic Azad Univ, Fac Sci, Dept Biol, Sci & Res Branch, Tehran, Iran

[7] Univ Silesiaia Katowice Poland, Institutitue Biol Biotechnol & Environm Protect, Fac Nat Sci, Katowice, Poland

[8] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[9] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran

[10] Tabriz Univ Med Sci, Fac Pharm, Dept Med Chem, Tabriz, Iran

[11] Erasmus MC, Dept Biochem, Rotterdam, Netherlands

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 153卷

关键词：

Crocin; Cancer; Covid19; Anti-inflammatory; Anti-oxidant; INCREASED OXIDATIVE STRESS; ISCHEMIA/REPERFUSION INJURY; PHARMACOKINETIC PROPERTIES; ENDOTHELIAL DYSFUNCTION; INDUCED CARDIOTOXICITY; VOLUNTARY EXERCISE; CONSTITUENT CROCIN; CEREBRAL-ISCHEMIA; GASTRIC-CARCINOMA; SAFFRON EXTRACT;

D O I：

10.1016/j.biopha.2022.113297

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Crocin, an active ingredient derived from saffron, is one of the herbal components that has recently been considered by researchers. Crocin has been shown to have many anti-inflammatory and antioxidant properties, and therefore can be used to treat various diseases. It has been shown that Crocin has a positive effect on the prevention and treatment of cardiovascular disease, cancer, diabetes, and kidney disease. In addition, the role of this substance in COVID-19 pandemic has been identified. In this review article, we tried to have a comprehensive review of the antioxidant and anti-inflammatory effects of Crocin in different diseases and different tissues. In conclusion, Crocin may be helpful in pathological conditions that are associated with inflammation and oxidative stress.

引用

页数：13

共 245 条

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Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations [J].