Time scale of entropic segregation of flexible polymers in confinement: Implications for chromosome segregation in filamentous bacteria

被引：51

作者：

Arnold, Axel

Jun, Suckjoon

机构：

[1] FOM, Inst AMOLF, NL-1098 SJ Amsterdam, Netherlands

[2] Fac Med, INSERM Site Necker, U571, F-75015 Paris, France

来源：

PHYSICAL REVIEW E | 2007年 / 76卷 / 03期

关键词：

D O I：

10.1103/PhysRevE.76.031901

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We report molecular dynamics simulations of the segregation of two overlapping chains in cylindrical confinement. We find that the entropic repulsion between chains can be sufficiently strong to cause segregation on a time scale that is short compared to the one for diffusion. This result implies that entropic driving forces are sufficiently strong to cause rapid bacterial chromosome segregation.

引用

页数：5

共 19 条

[1]

Alberts B., 2002, Molecular Biology of The Cell, V4th

[2]

ARNOLD A, UNPUB

[3] Chromosome and replisome dynamics in E. coli:: Loss of sister cohesion triggers global chromosome movement and mediates chromosome segregation [J].