Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes are noncompetitive

被引：6

作者：

Yamada, T

Uchiyama, H

Nagata, T

Uchijima, M

Suda, T

Chida, K

Nakamura, H

Koide, Y

机构：

[1] Hamamatsu Univ Sch Med, Dept Microbiol & Immunol, Hamamatsu, Shizuoka 4313192, Japan

[2] Hamamatsu Univ Sch Med, Dept Internal Med 2, Hamamatsu, Shizuoka 4313192, Japan

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 05期

关键词：

D O I：

10.1128/IAI.69.5.3427-3430.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Taking advantage of the bet that plasmid DNA encoding a single cytotoxic T lymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity.

引用

页码：3427 / 3430

页数：4

共 31 条

[1] MECHANISMS INFLUENCING THE IMMUNODOMINANCE OF T-CELL DETERMINANTS [J].