Panton valentine leukocidin (PVL) toxin positive MRSA strains isolated from companion animals

被引：100

作者：

Rankin, S

Roberts, S

O'Shea, K

Maloney, D

Lorenzo, M

Benson, CE

机构：

[1] Univ Penn, Mathew J Ryan Vet Hosp, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Vet Med, Philadelphia, PA 19104 USA

[3] Univ Penn, New Bolton Ctr, Kennett Sq, PA 19148 USA

来源：

VETERINARY MICROBIOLOGY | 2005年 / 108卷 / 1-2期

关键词：

panton valentine leukocidin (PVL); methicillin-resistant Staphylococcus aureus (MRSA);

D O I：

10.1016/j.vetmic.2005.02.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Methicillin-resistant Staphylococcus aureus (MRSA) is a highly pathogenic multiple-drug resistant (MDR) microorganism that has recently become more prevalent in the community. It has been found that MRSA strains can also contain genes that encode the panton valentine leukocidin toxin (PVL). The PVL toxin has been shown to be responsible for many of the severe clinical symptoms of infection with MRSA, such as furunculosis, severe necrotizing pneumonia, and necrotic lesions of the skin and soft tissues. The aim of this study was to determine the presence of the S. aureus PVL toxin genes (lukS-PV and lukF-PV) in MRSA strains isolated from companion animals. Eleven MRSA isolates, from a total of 23 tested, were shown to possess the mecA gene and the PVL toxin genes. Pulsed-field gel electrophoresis showed that the 11 PVL toxin positive MRSA strains were highly clonal. (c) 2005 Elsevier B.V. All rights reserved.

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页码：145 / 148

页数：4

相关论文

共 16 条

[1] HUMAN CARRIAGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS LINKED WITH PET DOG [J].

CEFAI, C ;

ASHURST, S ;

OWENS, C .

LANCET, 1994, 344 (8921) :539-540

[2] How clonal is Staphylococcus aureus? [J].

Feil, EJ ;

Cooper, JE ;

Grundmann, H ;

Robinson, DA ;

Enright, MC ;

Berendt, T ;

Peacock, SJ ;

Smith, JM ;

Murphy, M ;

Spratt, BG ;

Moore, CE ;

Day, NPJ .

JOURNAL OF BACTERIOLOGY, 2003, 185 (11) :3307-3316

[3] Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients [J].

Gillet, Y ;

Issartel, B ;

Vanhems, P ;

Fournet, JC ;

Lina, G ;

Bes, M ;

Vandenesch, F ;

Piémont, Y ;

Brousse, N ;

Floret, D ;

Etienne, J .

LANCET, 2002, 359 (9308) :753-759

[4]

Gortel K, 1999, AM J VET RES, V60, P1526

[5] Pet animals as reservoirs of antimicrobial-resistant bacteria [J].

Guardabassi, L ;

Schwarz, S ;

Lloyd, DH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (02) :321-332

[6] Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia [J].

Lina, G ;

Piémont, Y ;

Godail-Gamot, F ;

Bes, M ;

Peter, MO ;

Gauduchon, V ;

Vandenesch, F ;

Etienne, J .

CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) :1128-1132

[7] Asymptomatic nasal carriage of mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts [J].

Manian, FA .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (02) :E26-E28

[8] Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States:: Establishing a national database [J].

McDougal, LK ;

Steward, CD ;

Killgore, GE ;

Chaitram, JM ;

McAllister, SK ;

Tenover, FC .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (11) :5113-5120

[9]

Pak SI, 1999, J VET MED SCI, V61, P1013

[10] A real-time PCR assay to detect the Panton Valentine Leukocidin toxin in staphylococci:: screening Staphylococcus schleiferi subspecies coagulans strains from companion animals [J].

Roberts, S ;

O'Shea, K ;

Morris, D ;

Robb, A ;

Morrison, D ;

Rankin, S .

VETERINARY MICROBIOLOGY, 2005, 107 (1-2) :139-144