Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein

被引:83
作者
Diaz, JJ
Dodon, MD
SchaererUthurralt, N
Simonin, D
Kindbeiter, K
Gazzolo, L
Madjar, JJ
机构
[1] Immuno-Virologie Molec. et Cell., Univ. Claude Bernard Lyon-1/CNRS U., Faculté de Médecine, 69372 Lyon CEDEX 08, rue Guillaume Paradin
关键词
D O I
10.1038/379273a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
HERPES simplex virus type 1 (HSV-1) Us11 protein, a true late gene product packaged within the virion, is delivered into cells after infection, exhibits a nucleocytoplasmic localization at early times, and later accumulates in the nucleoli(1-5). This RNA-binding basic phosphoprotein, capable of oligomerization, is supposed to be involved in post-transcriptional regulation of gene expression after HSV-1 infection(6,7). Expression of human T-cell leukaemia/lymphoma virus type-I (HTLV-I) and of human immunodeficiency virus type 1 (HIV-1) is post-transcriptionally regulated by Rex and Rev, respectively(8). These proteins are required for the cytoplasmic expression of unspliced gag-pol and singly spliced env transcripts(9,10). Here we show that HSV-1 Us11 protein is able to bind Rex- and Rev-responsive elements and to transactivate envelope retroviral glycoprotein expression.
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页码:273 / 277
页数:5
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