Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on "The relationship between dose of vitamin E and suppression of oxidative stress in humans"

被引:29
作者
Blumberg, Jeffrey B.
Frei, Balz
机构
[1] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
[2] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA
关键词
D O I
10.1016/j.freeradbiomed.2007.08.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1374 / 1376
页数:3
相关论文
共 15 条
  • [1] Mortality in randomized trials of antioxidant supplements for primary and secondary prevention - Systematic review and meta-analysis
    Bjelakovic, Goran
    Nikolova, Dimitrinka
    Gluud, Lise Lotte
    Simonetti, Rosa G.
    Gluud, Christian
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (08): : 842 - 857
  • [2] Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors
    Chiabrando, C
    Avanzini, F
    Rivalta, C
    Colombo, F
    Fanelli, R
    Palumbo, G
    Roncaglioni, MC
    [J]. CURRENT CONTROLLED TRIALS IN CARDIOVASCULAR MEDICINE, 2002, 3 (1):
  • [3] A Randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women - Results from the women's antioxidant cardiovascular study
    Cook, Nancy R.
    Albert, Christine M.
    Gaziano, J. Michael
    Zaharris, Elaine
    MacFadyen, Jean
    Danielson, Eleanor
    Buring, Julie E.
    Manson, JoAnn E.
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (15) : 1610 - 1618
  • [4] Lipid peroxidation cannot be used as a universal criterion of oxidative stress
    Dotan, Y
    Lichtenberg, D
    Pinchuk, I
    [J]. PROGRESS IN LIPID RESEARCH, 2004, 43 (03) : 200 - 227
  • [5] *FOOD NUTR BOARD I, 2000, DIET REF INT VIT C V, P186
  • [6] Vitamin E supplements: Good in theory, but is the theory good?
    Greenberg, ER
    [J]. ANNALS OF INTERNAL MEDICINE, 2005, 142 (01) : 75 - 76
  • [7] Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts
    Knekt, P
    Ritz, J
    Pereira, MA
    O'Reilly, EJ
    Augustsson, K
    Fraser, GE
    Goldbourt, U
    Heitmann, BL
    Hallmans, G
    Liu, SM
    Spiegelman, D
    Stevens, J
    Virtamo, J
    Willett, WC
    Rimm, EB
    Ascherio, A
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 80 (06) : 1508 - 1520
  • [8] Vitamin E in the primary prevention of cardiovascular disease and cancer - The Women's Health Study: A randomized controlled trial
    Lee, IM
    Cook, NR
    Gaziano, JM
    Gordon, D
    Ridker, PM
    Manson, JE
    Hennekens, CH
    Buring, JE
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (01): : 56 - 65
  • [9] Leonard SW, 2004, AM J CLIN NUTR, V79, P86
  • [10] A new recommended dietary allowance of vitamin C for healthy young women
    Levine, M
    Wang, YH
    Padayatty, SJ
    Morrow, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) : 9842 - 9846