Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albumin

被引：111

作者：

Ang, Wee Han

Daldini, Elisa

Juillerat-Jeanneret, Lucienne

Dyson, Paul J. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[2] CHU Vaudois, Univ Inst Pathol, CH-1011 Lausanne, Switzerland

来源：

INORGANIC CHEMISTRY | 2007年 / 46卷 / 22期

关键词：

D O I：

10.1021/ic701474m

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In order to utilize macromolecules for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein molecules was developed. The approach involves the design of a drug fragment capable of conjugating to linker molecules on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described.

引用

收藏

页码：9048 / 9050

页数：3

相关论文

共 18 条

[1] Ruthenium antimetastatic agents [J].

Alessio, E ;

Mestroni, G ;

Bergamo, A ;

Sava, G .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (15) :1525-1535

[2] Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis [J].

Ang, Wee Han ;

Daldini, Elisa ;

Scolaro, Claudine ;

Scopelliti, Rosario ;

Juillerat-Jeannerat, Lucienne ;

Dyson, Paul J. .

INORGANIC CHEMISTRY, 2006, 45 (22) :9006-9013

[3] Classical and non-classical ruthenium-based anticancer drugs: Towards targeted chemotherapy [J].

Ang, Wee Han ;

Dyson, Paul J. .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2006, (20) :4003-4018

[4]

Chuang VTG, 2002, PHARMACEUT RES, V19, P569

[5] Preparation, characterization and properties in vitro and in vivo of a paclitaxel-albumin conjugate [J].

Dosio, F ;

Brusa, P ;

Crosasso, P ;

Arpicco, S ;

Cattel, L .

JOURNAL OF CONTROLLED RELEASE, 1997, 47 (03) :293-304

[6] Metal-based antitumour drugs in the post genomic era [J].

Dyson, PJ ;

Sava, G .

DALTON TRANSACTIONS, 2006, (16) :1929-1933

[7] pKa estimation of ruthenium(II)-arene PTA complexes and their hydrolysis products via a DFT/continuum electrostatics approach [J].

Gossens, Christian ;

Dorcier, Antoine ;

Dyson, Paul J. ;

Rothlisberger, Ursula .

ORGANOMETALLICS, 2007, 26 (16) :3969-3975

[8] Polymer therapeutics: Concepts and applications [J].

Haag, R ;

Kratz, F .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (08) :1198-1215

[9] From bench to bedside -: preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A) [J].

Hartinger, Christian G. ;

Zorbas-Seifried, Stefanie ;

Jakupec, Michael A. ;

Kynast, Bernd ;

Zorbas, Haralabos ;

Keppler, Bernhard K. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2006, 100 (5-6) :891-904

[10]

Jakupec M.A., 2005, J CLIN PHARM THER, V43, P595