Maxi-K potassium channels: Form, function, and modulation of a class of endogenous regulators of intracellular calcium

被引：101

作者：

Gribkoff, VK

Starrett, JE

Dworetzky, SI

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Neurosci & Genitourinary Drug Discovery, Dept 409, Wallingford, CT 06492 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Neurosci & Genitourinary Chem, Wallingford, CT 06492 USA

来源：

NEUROSCIENTIST | 2001年 / 7卷 / 02期

关键词：

potassium channel; maxi-K channel; BK channel; slo channel; neuron; ischemia;

D O I：

10.1177/107385840100700211

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Large-conductance calcium-activated (maxi-K, BK) potassium channels are widely distributed in the brain, Maxi-K channels function as neuronal calcium sensors and contribute to the control of cellular excitability and the regulation of neurotransmitter release. Little is currently known of any significant role of maxi-K channels in the genesis of neurological disease. Recent advances in the molecular biology and pharmacology of these channels have revealed sources of phenotypic variability and demonstrated that they can be successfully modulated by pharmacological agents. A potential role is suggested in the treatment of conditions such as ischemic stroke and cognitive disorders.

引用

页码：166 / 177

页数：12

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