HuR and mRNA stability

被引：1030

作者：

Brennan, CM ^{[1
]}

Steitz, JA ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biophys & Biochem, New Haven, CT 06536 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2001年 / 58卷 / 02期

关键词：

AU-rich element; ELAV; Hu proteins; stress; nuclear export; mRNA stability;

D O I：

10.1007/PL00000854

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

An important mechanism of posttranscriptional gene regulation in mammalian cells is the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in their 3' untranslated regions. HuR, a ubiquitously expressed member of the Hu family of RNA-binding proteins related to Drosophila ELAV, selectively binds AREs and stabilizes ARE-containing mRNAs when overexpressed in cultured cells. This review discusses mRNA decay as a general form of gene regulation, decay signaled by AREs, and the role of HuR and its Hu-family relatives in antagonizing this mRNA degradation pathway. The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change.

引用

页码：266 / 277

页数：12

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