Cortical intercorrelations of temporal area volumes in schizophrenia

被引:45
作者
Mitelman, SA [1 ]
Shihabuddin, L [1 ]
Brickman, AM [1 ]
Buchsbaum, MS [1 ]
机构
[1] Mt Sinai Hosp, Dept Psychiat, Neurosci PET Lab, New York, NY 10029 USA
关键词
MRI; schizophrenia; interregional correlations; temporal lobe; Brodmann's areas; poor outcome;
D O I
10.1016/j.schres.2005.01.010
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. Methods: MR images were acquired in normal subjects (n=46) and patients with schizophrenia (n=106), divided into good-outcome (n=52) and poor-outcome (Kraepelinian; n=54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Results: Positive frontotemporal intercorrelations were significantly stronger while negative frontotemporal intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Conclusions: Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:207 / 229
页数:23
相关论文
共 78 条
[1]  
AITKIN MA, 1969, BIOMETRIKA, V56, P443, DOI 10.2307/2334438
[2]  
Akbarian S, 1996, ARCH GEN PSYCHIAT, V53, P425
[3]   An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia [J].
Anderson, JE ;
Wible, CG ;
McCarley, RW ;
Jakab, M ;
Kasai, K ;
Shenton, ME .
SCHIZOPHRENIA RESEARCH, 2002, 58 (2-3) :123-134
[4]  
ANDREASEN NC, 1992, ARCH GEN PSYCHIAT, V49, P615
[5]  
BAN T, 1991, ARCH ITAL BIOL, V129, P259
[6]   Mosaic evolution of brain structure in mammals [J].
Barton, RA ;
Harvey, PH .
NATURE, 2000, 405 (6790) :1055-1058
[7]   Evolutionary coherence of the mammalian amygdala [J].
Barton, RA ;
Aggleton, JP ;
Grenyer, R .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2003, 270 (1514) :539-543
[8]  
BREIER A, 1992, ARCH GEN PSYCHIAT, V49, P921
[9]   Caudate and putamen volumes in good and poor outcome patients with schizophrenia [J].
Buchsbaum, MS ;
Shihabuddin, L ;
Brickman, AM ;
Miozzo, R ;
Prikryl, R ;
Shaw, R ;
Davis, K .
SCHIZOPHRENIA RESEARCH, 2003, 64 (01) :53-62
[10]   The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia [J].
Bullmore, ET ;
Frangou, S ;
Murray, RM .
SCHIZOPHRENIA RESEARCH, 1997, 28 (2-3) :143-156