Anaphylaxis to celecoxib

被引：48

作者：

Levy, MB ^{[1
]}

Fink, JN ^{[1
]}

机构：

[1] Med Coll Wisconsin, Allergy Immunol Sect, Dept Pediat & Med, Milwaukee, WI 53201 USA

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2001年 / 87卷 / 01期

关键词：

D O I：

10.1016/S1081-1206(10)62327-7

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Adverse reactions such as urticaria, angioedema, asthma, and anaphylaxis are known to be associated with nonsteroidal anti-inflammatory agents (NSAIDs). Celecoxib (Pfizer/Searle, Caguas, PR) is a new NSAID that differs in structure and mechanism of action of other similar drugs of this class. Objective: Evaluation of a case of anaphylaxis to celecoxib (Celebrex). Methods and Results: This report describes a 55-year-old woman who experienced the acute onset of pruritus, urticaria, respiratory distress, and hypotension minutes after ingesting a celecoxib capsule. She had taken the drug a previous time for tendonitis without difficulty. Treatment with epinephrine, corticosteroids. and intravenous fluids was successful. An IgE mechanism could not be detected. She has avoided the drug and has had no further problems. Conclusions: This is the first patient report of anaphylaxis attributable to celecoxib, a new NSAID. This suggests that physicians and other health care professionals should be aware of the potential serious side effects of this drug.

引用

页码：72 / 73

页数：2