Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease

被引:43
作者
Canals, JM
Marco, S
Checa, N
Michels, A
Pérez-Navarro, E
Arenas, E
Alberch, J
机构
[1] Univ Barcelona, Fac Med, IDIBAPS, Dept Biol Cellular & Anat Patol, E-08036 Barcelona, Spain
[2] Karolinska Inst, Dept Med Biochem & Biophys, Mol Neurobiol Lab, S-17177 Stockholm, Sweden
关键词
D O I
10.1006/nbdi.1998.0211
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the present study we have evaluated changes in nerve growth factor (NGF),: brain-derived neurotrophic factor, and neurotrophin 3 (NT-3) mRNA expression induced by different glutamate receptor agonists injected into the neostriatum. Up-regulation of NGF expression was observed at 24 h after intrastriatal quinolinate injection, an N-methyl-D-aspartate receptor agonist, and this increase was maintained up to 7 days after lesion. NGF up-regulation was also apparent in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) treatment from 6 to 16 h postinjection. Instead, BDNF was up-regulated only at 6 h after kainate or AMPA excitotoxicity. Interestingly, NT-3 mRNA was down-regulated from 10 to 16 h following AMPA lesion, while 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid injection enhanced NT-3 mRNA levels at 10 h. Our results show a specific neurotrophin response induced by stimulation of each glutamate receptor. These activity-dependent changes might be involved in neuronal plasticity processes and may underlie the differential vulnerability of striatal neurons observed in neurodegenerative disorders. (C) 1998 Academic Press.
引用
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页码:357 / 364
页数:8
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