ERAD: the long road to destruction

被引：973

作者：

Meusser, B ^{[1
]}

Hirsch, C ^{[1
]}

Jarosch, E ^{[1
]}

Sommer, T ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1038/ncb0805-766

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or unassembled proteins from the ER. ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin-proteasome system (UPS). The spatial separation between substrate selection and degradation in ERAD requires substrate transport from the ER to the cytoplasm by a process termed dislocation. In this review, we will summarize advances in various aspects of ERAD and discuss new findings on how substrate dislocation is achieved.

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页码：766 / 772

页数：7

相关论文

共 98 条

[1] Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44 [J].

Anelli, T ;

Alessio, M ;

Bachi, A ;

Bergamelli, L ;

Bertoli, G ;

Camerini, S ;

Mezghrani, A ;

Ruffato, E ;

Simmen, T ;

Sitia, R .

EMBO JOURNAL, 2003, 22 (19) :5015-5022

[2] Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation [J].

Bays, NW ;

Gardner, RG ;

Seelig, LP ;

Joazeiro, CA ;

Hampton, RY .

NATURE CELL BIOLOGY, 2001, 3 (01) :24-29

[3] HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins [J].

Bays, NW ;

Wilhovsky, SK ;

Goradia, A ;

Hodgkiss-Harlow, K ;

Hampton, RY .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (12) :4114-4128

[4] Role of Cue1p in ubiquitination and degradation at the ER surface [J].

Biederer, T ;

Volkwein, C ;

Sommer, T .

SCIENCE, 1997, 278 (5344) :1806-1809

[5] Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway [J].

Biederer, T ;

Volkwein, C ;

Sommer, T .

EMBO JOURNAL, 1996, 15 (09) :2069-2076

[6] A glycosylated type I membrane protein becomes cytosolic when peptide:: N-glycanase is compromised [J].

Blom, D ;

Hirsch, C ;

Stern, P ;

Tortorella, D ;

Ploegh, HL .

EMBO JOURNAL, 2004, 23 (03) :650-658

[7] PRE-GOLGI DEGRADATION OF NEWLY SYNTHESIZED T-CELL ANTIGEN RECEPTOR CHAINS - INTRINSIC SENSITIVITY AND THE ROLE OF SUBUNIT ASSEMBLY [J].

BONIFACINO, JS ;

SUZUKI, CK ;

LIPPINCOTTSCHWARTZ, J ;

WEISSMAN, AM ;

KLAUSNER, RD .

JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :73-83

[8] De3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins [J].

Bordallo, J ;

Plemper, RK ;

Finger, A ;

Wolf, DH .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (01) :209-222

[9] THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VPU PROTEIN SPECIFICALLY BINDS TO THE CYTOPLASMIC DOMAIN OF CD4 - IMPLICATIONS FOR THE MECHANISM OF DEGRADATION [J].

BOUR, S ;

SCHUBERT, U ;

STREBEL, K .

JOURNAL OF VIROLOGY, 1995, 69 (03) :1510-1520

[10] Role of the ubiquitin-selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates [J].

Braun, S ;

Matuschewski, K ;

Rape, M ;

Thoms, S ;

Jentsch, S .

EMBO JOURNAL, 2002, 21 (04) :615-621

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