Cone venom - from accidental stings to deliberate injection

被引：95

作者：

McIntosh, JM

Jones, RM

机构：

[1] Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

[3] Cognetix Inc, Salt Lake City, UT USA

来源：

TOXICON | 2001年 / 39卷 / 10期

关键词：

Conus; conotoxin; human; medicine; envenomation;

D O I：

10.1016/S0041-0101(01)00145-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cone snails have long been of note due to their colorful shells and deadly venom. Over the years, a number of people who have encountered these molluscs have been injured or killed by their sting. Biochemical analysis of the venom components has revealed a plethora of peptides and proteins that target a variety of receptors and ion channels. Pharmaceutical companies are now utilizing the selectivity and potency of Conus-derived peptides to develop novel medications for pain, epilepsy and other disorders. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1447 / 1451

页数：5

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