FTD and ALS: Genetic Ties that Bind

被引：26

作者：

Orr, Harry T. ^{[1
]}

机构：

[1] Univ Minnesota, Inst Translat Neurosci, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

来源：

NEURON | 2011年 / 72卷 / 02期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; TDP-43;

D O I：

10.1016/j.neuron.2011.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.

引用

页码：189 / 190

页数：2

共 8 条

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