Comprehensive two-dimensional gas chromatography in metabolomics

被引：86

作者：

Almstetter, Martin F. ^{[1
]}

Oefner, Peter J. ^{[1
]}

Dettmer, Katja ^{[1
]}

机构：

[1] Univ Regensburg, Inst Funct Genom, D-93053 Regensburg, Germany

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2012年 / 402卷 / 06期

关键词：

Metabolomics; Metabolite profiling; Metabolic fingerprinting; Comprehensive two-dimensional gas chromatography; FLIGHT-MASS-SPECTROMETRY; METHYLOBACTERIUM-EXTORQUENS AM1; GC-TOFMS DATA; PARALLEL FACTOR-ANALYSIS; X GC; SYSTEMS BIOLOGY; CHLAMYDOMONAS-REINHARDTII; AMINO-ACIDS; CHEMOMETRIC ANALYSIS; FUNCTIONAL GENOMICS;

D O I：

10.1007/s00216-011-5630-y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC x GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC x GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.

引用

页码：1993 / 2013

页数：21

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