Neuropsychiatric disturbances in Parkinson's disease clusters in five groups with different prevalence of dementia

被引：49

作者：

Bronnick, K

Aarsland, D

Larsen, JP

机构：

[1] Stavanger Univ Hosp, Helse Stavanger, Sect Geriatr Psychiat, N-4068 Stavanger, Norway

[2] Stavanger Univ Hosp, Helse Stavanger, Dept Neurol, N-4068 Stavanger, Norway

[3] Univ Bergen, Sch Med, Bergen, Norway

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2005年 / 112卷 / 03期

关键词：

Parkinson's disease; classification; dementia; depression;

D O I：

10.1111/j.1600-0447.2005.00562.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To investigate the inter-relationship of neuropsychiatric disturbances in Parkinson's disease (PD) by cluster analysis and describe the properties of the clusters. Method: A total of 139 patients were assessed using the neuropsychiatric inventory (NPI). A cluster-analysis was used to investigate the inter-relationship of NPI items. The clusters were profiled regarding dementia (PDD) and major depression. Results: A total of 39 patients showed no neuropsychiatric symptoms. The remaining 100 patients (43% PDD) were divided in to five clusters. The largest group (42, 31% PDD) showed symptoms of mild depression, followed by a group (29, 79.3% PDD) with hallucinations and mild other symptoms. The third group (14, 7.1% PDD) had sleep disturbances exclusively. The fourth group (8, 25% PDD) showed apathy, anxiety and depression. The smallest group (7, 57.1% PDD) had high scores on several NPI items. Conclusion: Our PD sample can be divided in to clusters based on the NPI, with different prevalence of dementia and depression.

引用

页码：201 / 207

页数：7

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