Sympathetic hyperactivity in Wistar rats with insulin-resistance

被引：9

作者：

Chang, CJ

Wu, JS

Lu, FH

Liu, IM

Chi, TC

Cheng, JT ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Family Med, Tainan 70101, Taiwan

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1998年 / 74卷 / 2-3期

关键词：

sympathetic nervous system; insulin-resistance; glucose tolerance test; Wistar rat;

D O I：

10.1016/S0165-1838(98)00143-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In an attempt to know the effect of sustained hyperinsulinemia on sympathetic function, plasma norepinephrine (NE) and glucose levels were measured in Wistar rats with insulin resistance. Both the basal plasma glucose and the plasma NE levels in insulin-resistant rats were markedly higher than that obtained in normal or streptozotocin (STZ)-induced diabetic rats. Treatment with guanethidine and prazosin reversed these sympathetic hyperactive responses in insulin-resistant rats. Moreover, increase of plasma insulin in rats receiving an intraperitoneal glucose challenge test confirmed the mediation of endogenous insulin in this sympathetic hyperactivity. These results suggest an increase of sympathetic activity in insulin-resistant state that may be related to the hypertension-prone associated with diabetes mellitus in clinics. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：116 / 119

页数：4

共 24 条

[1] THE VASODILATOR ACTION OF INSULIN - IMPLICATIONS FOR THE INSULIN HYPOTHESIS OF HYPERTENSION [J].