Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine

被引：21

作者：

Tsuzuki, Y ^{[1
]}

Chiba, K ^{[1
]}

Hino, K ^{[1
]}

机构：

[1] Dainippon Pharmaceut Co Ltd, Discovery Res Labs, Suita, Osaka 5640053, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(01)00302-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate for a novel quinolone antitumor agent AG-7352 is presented. Starting from either D- Or L-tartaric acid, a stereospecific synthesis of the chiral pyrrolidine was achieved via two S(N)2 displacement reactions. From the results of this synthetic study, the absolute structure of AG-7352 was chemically determined. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1793 / 1799

页数：7

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