Osteomyelitis and diabetic osteoarthropathy result in increased uptake of bone-imaging agents on bone scans. Labeled leukocytes and bone marrow scans have an established role in differentiating the two diseases. However, this method suffers from poor spatial resolution, which may result in erroneous findings. Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a feasible method to detect infection. This interesting case shows that FDG PET is helpful in differentiating septic arthritis from diabetic osteoarthropathy.