Chimeric Antigen Receptors in Cancer Immuno-Gene Therapy: Current Status and Future Directions

被引：17

作者：

Chicaybam, Leonardo ^{[1
]}

Sodre, Andressa Laino ^{[1
]}

Bonamino, Martin ^{[1
]}

机构：

[1] Inst Nacl Canc, Div Expt Med, BR-20231050 Rio De Janeiro, Brazil

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2011年 / 30卷 / 5-6期

关键词：

Chimeric Antigen Receptors; Cancer; Gene Therapy; Immunotherapy; T-CELL-RECEPTOR; II-RESTRICTED PHOSPHOPEPTIDES; CHRONIC LYMPHOCYTIC-LEUKEMIA; VERSUS-HOST-DISEASE; ADOPTIVE TRANSFER; ANTITUMOR-ACTIVITY; SUICIDE GENE; IN-VITRO; ENHANCED SURVIVAL; ADVERSE EVENT;

D O I：

10.3109/08830185.2011.595855

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensive application of CARs in tumor immunotherapy. We describe here the fundaments of these molecules in terms of structure, function, possible targets and preclinical and clinical applications. We also discuss strategies that can potentially overcome the limitations seen so far, paving the road to a wider application of this exciting new technology.

引用

页码：294 / 311

页数：18

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