The unique characteristics of COVID-19 coagulopathy

被引：289

作者：

Iba, Toshiaki ^{[1
]}

Levy, Jerrold H. ^{[2
]}

Connors, Jean Marie ^{[3
]}

Warkentin, Theodore E. ^{[4
,5
]}

Thachil, Jecko ^{[6
]}

Levi, Marcel ^{[7
,8
]}

机构：

[1] Juntendo Univ, Grad Sch Med, Dept Emergency & Disaster Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan

[2] Duke Univ, Sch Med, Dept Anesthesiol Crit Care & Surg, Durham, NC USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Hematol Div, Boston, MA 02115 USA

[4] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

[5] McMaster Univ, Dept Med, Hamilton, ON, Canada

[6] Manchester Royal Infirm, Dept Haematol, Manchester, Lancs, England

[7] Univ Coll London Hosp NHS Fdn Trust, Dept Med, London, England

[8] Cardiometab Programme NIHR UCLH UCL BRC London, London, England

来源：

CRITICAL CARE | 2020年 / 24卷 / 01期

关键词：

COVID-19; Coagulopathy; Disseminated intravascular coagulation; Hemophagocytic syndrome; Antiphospholipid syndrome; Thrombotic microangiopathy; CORONAVIRUS DISEASE 2019; ANTIPHOSPHOLIPID SYNDROME; THERAPEUTIC GUIDELINES; CYTOKINE STORM; MANAGEMENT; DIAGNOSIS; INFECTION; RISK;

D O I：

10.1186/s13054-020-03077-0

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.

引用

页数：8

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