Design and synthesis of 6-(6-D-ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexylphosphonic acid, a potent inhibitor of lumazine synthase

被引：18

作者：

Cushman, M ^{[1
]}

Mihalic, JT

Kis, K

Bacher, A

机构：

[1] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

[2] Tech Univ Munich, Lehrstuhl Organ Chem & Biochem, D-85747 Garching, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(98)00687-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel inhibitor of lumazine synthase, the penulrimate enzyme in the biosynthesis of riboflavin, has been synthesized. The inhibitor was designed by computer graphics molecular modeling using a hypothetical structure of the enzyme-inhibitor complex. The new compound is relatively potent when compared with the known inhibitors, and displays a K-I of 109 mu M. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：39 / 42

页数：4

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