The isolation and synthesis of novel nematocidal dithiocyanates from an Australian marine sponge, Oceanapia sp.

被引：59

作者：

Capon, RJ ^{[1
]}

Skene, C ^{[1
]}

Liu, EHT ^{[1
]}

Lacey, E ^{[1
]}

Gill, JH ^{[1
]}

Heiland, K ^{[1
]}

Friedel, T ^{[1
]}

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 23期

关键词：

D O I：

10.1021/jo0106750

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-directed fractionation of the EtOH extract of an Oceanapia sp. collected off the northern Rottnest Shelf, Australia, has yielded three novel dithiocyanates, thiocyanatins A (1), B (2a), and C (2b). The structures were determined by detailed spectroscopic analysis and confirmed by total synthesis. In addition to featuring an unprecedented dithiocyanate functionality, thiocyanatins possess an unusual 1,16-difunctionalized n-hexadecane carbon skeleton and are revealed as a hitherto unknown class of nematocidal agents

引用

页码：7765 / 7769

页数：5

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