Synthetic methods for γ-lactam and pyrrole derivatives exploiting a three-component coupling strategy

被引：15

作者：

Clique, B ^{[1
]}

Anselme, C ^{[1
]}

Otto, D ^{[1
]}

Monteiro, N ^{[1
]}

Balme, G ^{[1
]}

机构：

[1] Univ Lyon 1, Lab Chim Organ 1, CNRS, UMR 5181, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 06期

关键词：

lactams; pyrroles; hydrogenation; rearrangement; aromatization;

D O I：

10.1016/j.tetlet.2003.11.142

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Aryloxymethyl-3-pyrrolines and their isomeric pyrrolidines-assembled via a one-pot, three-component coupling of propargylic amines, vinyl sulfones, and phenols-may be elaborated further to provide an easy access to 2,4-disubstituted pyrrole-3-carboxylates and 3,4-disubstituted pyrrolidin-2-ones. The latter were prepared by means of an unprecedented rearrangement process involving hydrogenolysis of 2-aryl pyrrolidine-3-carboxylates, whereas the pyrrole carboxylates arose from aromatization of the corresponding pyrrolines. (C) 2003 Published by Elsevier Ltd.

引用

页码：1195 / 1197

页数：3

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